Active Components and Constitutional Formula
Chondroitin sulfate chains are unbranched polysaccharides of variable length containing two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc). Some GlcA residues are epimerized into L-iduronic acid (IdoA); the resulting disaccharide is then referred to as dermatan sulfate.
Chondroitin-4-sulfate: R1 = H; R2 = SO3H; R3 = H.
Chondroitin-6-sulfate: R1 = SO3H; R2, R3 = H.
Specification
Chondroitin Sulphate Bovine
Chondroitin Sulphate Porcine
Chondroitin Sulphate Chicken
Chondroitin Sulphate Shark
Calcium Chondroitin Sulphate
Certificate of Analysis
ITEMS
|
SPECIFICATION
|
Appearance
|
Creamy white powder
|
Odor
|
Characteristic
|
Taste
|
Characteristic
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Solubility and Clarity
|
Soluble in water, clear
|
Assay
|
90%, HPLC
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Protein Content
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≤3.0%
|
Sodium Identification
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Positive
|
pH Value
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5.5-7.5
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Specific Rotation (3% Sol.)
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-20~ -30°
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Chlorides
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<0.50%
|
Loss On Drying
|
≤10.0%, 5g / 105℃ / 2hrs
|
Bulk Density
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≥0.60g/ml
|
Mesh size
|
100% Pass 80Mesh
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Residue on Ignition
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20-30%
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Heavy Metals
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≤10mg/Kg, Atomic Absorption
|
Total Plate Count
|
<1000 cfu/g
|
Yeast and Mold
|
<100 cfu/g
|
S. aureus
|
Negative
|
E. Coli
|
Negative
|
Salmonella
|
Negative
|
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Indications and Usage
Chondroitin sulfate is a sulfated glycosaminoglycan (GAG) composed of a chain of alternating sugars ( N-acetylgalactosamine and glucuronic acid). It is usually found attached to proteins as part of a proteoglycan. A chondroitin chain can have over 100 individual sugars, each of which can be sulfated in variable positions and quantities. Chondroitin sulfate is an important structural component of cartilage and provides much of its resistance to compression. Along with glucosamine, chondroitin sulfate has become a widely used dietary supplement for treatment of osteoarthritis.
Chondroitin is an ingredient found commonly in dietary supplements used as an alternative medicine to treat osteoarthritis and also approved and regulated as a symptomatic slow-acting drug for this disease (SYSADOA) in Europe and some other countries. It is commonly sold together with glucosamine. Chondroitin and glucosamine are also used in veterinary medicine.
The dosage of oral chondroitin used in human clinical trials is 800–1,200 mg per day. Most chondroitin appears to be made from extracts of cartilaginous cow and pig tissues (cow trachea and pig ear and nose), but other sources such as shark, fish, and bird cartilage are also used. Since chondroitin is not a uniform substance, and is naturally present in a wide variety of forms, the precise composition of each supplement will vary. The major cosmetic use of chondroitin sulphate is in skin creams. Chondroitin sulphate hold up 30 times its weight in water, an ability which gives it very good moisturizing properties.
Clinical studies have not identified any significant side-effects or overdoses of chondroitin sulfate, which suggest its long-term safety. Its safety is supported by an absence of drug-drug interactions (chondroitin sulfate is not metabolized by cytochrome), and the lack of safe alternatives for patients multi-medicated for osteoarthritis and other accompanying diseases, e.g. diabetes, hypertension, hyperlipidemia, etc.
Package
25kg/drum, double layers plastic bags inside.
Storage Situation
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat. |